Yeah what’s external from the body and mind of an individual is a whole other story aka the society in which they are in. It’s sometimes a dangerous perspective but I do tend to see issues more so as technological issues. With this circumstance it’s not an issue I see with an individual that they feel they don’t match their body but that our technology is so limited that we can’t change form as easily as we change clothes. The illness or lacking isn’t an aspect of the individual but in our current technological abilities as a species. With sufficient technology any will should be unbounded so long as it is not causing needless and avoidable suffering to another sentient being. If for instance we can upload a mind and inhabit a virtual space then we may achieve this sooner than we think. In what we consider “actual” or “physical” reality, it’s going to take a lot more time and effort.