On youtube, there is a channel called System Crafters, who has various videos explaining his system made up of guix system, emacs and EmacsWM. It’s the most unified operating system on GNU/Linux. If it fits your workflow, you can make the transition.

1. Superior Error handling and debugging(with Lisp REPL) thanks to Guile Scheme language.
2. Guile scheme is easier to write and understand. It has a mature ecosystem of libraries and standard programming constructs (macros, recursion, higher-order functions)
3. In Guix System, the package manager, the build system, and the system configuration are all written in the same language.
4. No systemd, Guix system uses GNU Shepherd. You define services directly in Guile Scheme. This allows for dynamic service manipulation, hot-swapping, and introspection using the same language as the rest of the system.
5. Guix home (the home manager) is built in and very easy to use if you already got the hang of Guile Scheme.
6. Guix uses linux-libre, which is fully free kernel. If your hardware is not supported (likely) there is a nonguix channel to get proprietary packages to make it work.
7. The standard guix repository contains only free software. Proprietary software can be installed via some other channels, but not recommended.

And the even more glorious, guix